| 达肝素钠在体内的分布部位不及未分馏肝素广泛 |
| 添加时间：2019/12/24 14:42:53 浏览次数： |
| 达肝素钠口服不能吸收，静脉注射后3min起效，最大效应时间为2～4h，半衰期约为2h；皮下注射后2～4h起效，最大效应时间为3min，达峰时间为3～4h，半衰期约为3～5h，生物利用度为87%，多次给药后，效应可维持10～24h。血浆中充分发挥抗血栓形成活性所需的抗-Ⅹa的治疗浓度波动范围在0.1～0.6U/ml之间。 Daparin sodium can't be absorbed by oral administration. It takes effect 3 minutes after intravenous injection, with the maximum effect time of 2-4 hours and half-life of 2 hours; it takes effect 2-4 hours after subcutaneous injection, with the maximum effect time of 3 minutes, with the peak time of 3-4 hours, half-life of 3-5 hours and bioavailability of 87%. After multiple administration, the effect can be maintained for 10-24 hours. The therapeutic concentration of anti XA required for the full use of antithrombotic activity in plasma fluctuated from 0.1 to 0.6u/ml. 预防急性前壁心肌梗死患者左心室血栓形成时，达肝素钠抗-Ⅹa的血药浓度为0.6～1.0U/ml；治疗急性静脉血栓形形形成所需的平均抗-Ⅹa血药浓度为0.5U/ml。达肝素钠在体内的分布部位不及未分馏肝素广泛，其分布容积（Vd）为40～60ml/kg或3～11L。达肝素钠主要经肾脏排泄，其肾脏清除率每分钟为20～30ml，肾功能不全者的半衰期可见延长。 In the prevention of left ventricular thrombosis in patients with acute anterior wall myocardial infarction, the serum concentration of heparin sodium for anti - XA was 0.6-1.0u/ml, and the average serum concentration of anti - XA for the treatment of acute venous thrombosis was 0.5u/ml. The distribution of daparin sodium in vivo is not as extensive as that of unfractionated heparin, and its distribution volume (VD) is 40-60ml / kg or 3-11l. The renal clearance rate was 20-30 ml per minute. The half-life of patients with renal insufficiency was prolonged. |
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