| 肝素钠抗凝原理 |
| 添加时间：2019/6/3 16:27:21 浏览次数： |
| 由于肝素钠具有带强负电荷的理化特性，能干扰血凝过程的许多环节，在体内外都有抗凝血作用。其作用机制比较复杂，主要通过与抗凝血酶Ⅲ（AT-Ⅲ）结合，而增强后者对活化的Ⅱa、Ⅸa、Ⅹa、Ⅺa和Ⅻa凝血因子的抑制作用。 Because heparin sodium has strong negative charge physical and chemical characteristics, it can interfere with many aspects of the hemagglutination process, and has anticoagulant effect in vivo and in vitro. Its mechanism of action is complex, mainly through the combination with antithrombin III (AT-III), and enhance the inhibition of the latter on activated coagulation factors II a, IX a, IX A and IX a. 其后果涉及阻止血小板凝集和破坏，妨碍凝血激活酶的形成；阻止凝血酶原变为凝血酶；抑制凝血酶，从而妨碍纤维蛋白原变成纤维蛋白。中和组织凝血活素（因子Ⅲ）。抑制血小板的聚集和释放。 The consequences involve preventing platelet aggregation and destruction, hindering the formation of www.zhangjiakoubanjia.cnwww.foxiangdiaoke.cnwww.yanglaoyua.cnwww.shiguanyin.cnwww.luomazh u.net.cn www.xingtaibanjia.com.cnthrombin activating enzymes, preventing prothrombin from turning into thrombin, and inhibiting thrombin, thereby preventing fibrinogen from turning into fibrin. Neutralize tissue thromboplastin (factor III). Inhibition of platelet aggregation and release. |
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