| 什么是肝素钠 |
| 添加时间：2018/11/24 15:37:53 浏览次数： |
| 肝素钠是由猪或牛的肠粘膜中提取的硫酸氨基葡聚糖的钠盐，属粘多糖类物质。由于肝素钠具有带强负电荷的理化特性，能干扰血凝过程的许多环节，在体内外都有抗凝血作用。其作用机制比较复杂，主要通过与抗凝血酶Ⅲ（AT-Ⅲ）结合，而增强后者对活化的Ⅱ、Ⅸ、Ⅹ、Ⅺ和Ⅻ凝血因子的抑制作用。能够阻止血小板聚集和破坏，妨碍凝血激活酶的形成；阻止凝血酶原变为凝血酶；抑制凝血酶，从而妨碍纤维蛋白原变成纤维蛋白，达到抗凝血的作用。 Heparin sodium is a sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs or cattle. It is a mucopolysaccharide substance. Because heparin sodium has strong negative charge physical and chemical characteristics, it can interfere with many aspects of the hemagglutination process, and has anticoagulant effect in vivo and in vitro. Its mechanism of action is complex, mainly through the combination with antithrombin III (AT-III), and enhance the latter's inhibition of activated coagulation factors II, IX, VII and VII. It can prevent platelet aggregation and destruction, hinder the formation of thrombin activator, prevent prothrombin from turning into thrombin, and inhibit thrombin, thus preventing fibrinogen from turning into fibrin, thus achieving anticoagulant effect. 肝素钠注射液用于防治血栓形成或栓塞性疾病（如心肌梗塞、血栓性静脉炎、肺栓塞等），各种原因引起的弥漫性血管内凝血（DIC），也用于血液透析、体外循环、导管术、微血管手术等操作中及某些血液标本或器械的抗凝处理。 Heparin sodium injection is used to prevent and treat thrombosis or embolic diseases (such as myocardial infarction, thrombophlebitis, pulmonary embolism, etc.) and diffuse intravascular coagulation (DIC) caused by various causes. It is also used in hemodialysis, cardiopulmonary bypass, catheterization, microvascular surgery and anticoagulation of some blood samples or instruments. Li. |
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